Knockout Fall Asleep Faster. Stay Asleep Longer.
Knockout combines three clinically selected ingredients to help you fall asleep faster, stay asleep longer, and wake up refreshed.
- Supports Deeper, More Restful Sleep
- Helps You Stay Asleep Longer
- Helps Reduce Nighttime Awakenings
- Wake Up Feeling Refreshed
- No Hidden Fees & No Membership
Discreet shipping on all orders
No insurance required
Fast provider decision
Take our short quiz to get pre-approved for an at-home prescription.
Knockout — Doxylamine Succinate 10mg / Trazodone 50mg / Melatonin 2.5mg
Knockout is a compounded oral swallowable formulation combining Doxylamine Succinate 10mg, Trazodone 50mg, and Melatonin 2.5mg, designed to support sleep initiation and maintenance through combined antihistamine, serotonergic, and circadian signaling pathways.
This preparation is intended for individualized use under the supervision of a licensed healthcare provider.
Doxylamine Succinate, Trazodone & Melatonin
Doxylamine Succinate is a first-generation antihistamine that promotes sedation through H1 receptor antagonism.
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) commonly used at low doses for its sedative effects and support of sleep continuity.
Melatonin is an endogenous hormone involved in circadian rhythm regulation and sleep-wake cycle signaling.
Knockout combines three mechanisms that target sleep initiation and maintenance: antihistamine sedation, serotonergic support for sleep continuity, and circadian signaling from melatonin.
Use only as prescribed by your healthcare provider, typically taken in the evening prior to bedtime. Avoid alcohol or other sedating agents unless directed by a clinician.
How it Works
Three easy steps to better sleep, backed by licensed medical guidance.
Step 1
Complete Your Sleep Assessment
Tell us about your sleep patterns, symptoms, medical history, and any medications you're currently taking.
Step 2
Personalized Provider Review
A licensed provider evaluates your information and determines the right sleep support option for you.
Step 3
Start Your Sleep Routine
If prescribed, your sleep support is sent to your preferred pharmacy or delivered directly to your door.
Knockout — What It Treats
Knockout combines Doxylamine Succinate, Trazodone, and Melatonin to support sleep initiation and maintenance through three complementary pathways. It's commonly considered when a single-mechanism approach hasn't been enough to fall asleep or stay asleep.
Understanding Knockout: Use & Safety
What it is
Knockout pairs an antihistamine (Doxylamine), a low-dose serotonergic agent (Trazodone), and Melatonin to target sleep initiation and maintenance from multiple angles.
Why it's different
This multi-pathway approach may help when sleep difficulty involves both falling asleep and staying asleep, not just one or the other.
Safety first
Knockout is more sedating than single-ingredient options. Avoid alcohol, use caution with cardiovascular risk, and don't combine with other sedatives without your provider's guidance.
When Better Sleep Needs A Stronger Solution.
Knockout is an advanced prescription sleep therapy that combines three clinically selected ingredients to help you fall asleep faster, stay asleep longer, and enjoy a more restful night's sleep. Designed for adults who need stronger overnight support, Knockout promotes consistent, restorative sleep so you can wake up feeling refreshed and ready for the day.
Every treatment begins with a confidential online consultation reviewed by a licensed healthcare provider. If Knockout is appropriate for your needs, your personalized prescription is delivered directly to your door—making it easier than ever to get the sleep support you deserve.
Patients Love Our Personalized Care
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50 states delivery
Delivery Across All 50 States
Fast and discreet shipping, wherever you are in the U.S.
Takashi Nakamura, MD
Board-Certified Emergency Medicine Physician
Dr. Nakamura specializes in holistic health and weight management via telehealth.
Takashi Nakamura, MD
Michael Wasef, MD
Board-Certified Internal Medicine Physician
Internal Medicine specialist focused on root-cause, patient-centered care via telemedicine.
Michael Wasef, MD
Laurie J. Mercier, MD
Chief Clinical Lead at Telegra
Laurie J. Mercier, MD, Chief Clinical Lead at Telegra, is a board-certified Family Medicine physician focused on evidence-based, patient-centered care.
Laurie J. Mercier, MD
Kimberli Hastings, NP
Family Nurse Practitioner
Family Medicine and Mental Health practitioner dedicated to collaborative, patient-centered care.
Kimberli Hastings, NP
Theresa Vergara, DNP, NP
Certified Nurse Practitioner
Theresa is a Columbia-trained Nurse Practitioner providing holistic, root-cause-focused care.
Theresa Vergara, DNP, NP
Kristine Clements, NP
Board Certified Family Nurse Practitioner
Board-certified Family Nurse Practitioner with 25+ years of experience, focused on functional medicine and patient-centered wellness.
Kristine Clements, NP
FAQs
Haven't found the answer? Reach out to us, and we will help you.
Yes, a prescription is required. You can complete a quick online consultation with our providers—no in-person visit needed.
Not always. Many sleep concerns can be evaluated online through a symptom review with a licensed provider. In some cases, a provider may recommend further evaluation if that's needed to safely address your symptoms.
Most patients hear back from a licensed provider within 24 hours.
If prescribed, your medication is shipped directly to your home in discreet packaging.
Some individuals choose to combine different wellness therapies based on their personal goals. Your healthcare provider can help determine whether a combination approach is appropriate for your needs and lifestyle.
If a provider determines that treatment is not appropriate, a full refund will be issued.
Possible effects related to doxylamine include daytime drowsiness, dry mouth, and other anticholinergic effects. Trazodone may cause drowsiness, dizziness, orthostatic hypotension, and rarely priapism. Melatonin may cause vivid dreams, headache, or morning grogginess. Your provider will discuss potential risks and benefits during your evaluation.
Knockout may not be appropriate for individuals with hypersensitivity to its ingredients, those taking other sedative medications without supervision, or those with significant cardiovascular or hypotension risk. Use caution in elderly patients due to fall risk. A provider will screen your medical history before prescribing.
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