SleepE — Finally Fall Asleep Naturally
SleepE combines Ramelteon and Magnesium L-Threonate to help you fall asleep naturally.
- Helps You Fall Asleep Faster
- Supports Your Natural Sleep Cycle
- Easy-to-Take Mint Chewable
- Provider-Reviewed Prescription Care
- No Hidden Fees & No Membership
Discreet shipping on all orders
No insurance required
Fast provider decision
Take our-short-quiz to get pre-approved for an at-home prescription.
SleepE — Ramelteon 10mg / Magnesium L-Threonate 250mg
SleepE is a compounded oral medication combining Ramelteon 10mg and Magnesium L-Threonate 250mg in a mint-flavored, green, chewable tablet. This formulation is designed to support circadian rhythm regulation and neurologic relaxation involved in sleep initiation.
SleepE may be considered for adult patients experiencing difficulty with sleep onset or circadian rhythm disruption when individualized therapy is clinically appropriate and prescribed by a licensed healthcare provider.
Ramelteon (10mg) & Magnesium L-Threonate (250mg)
Ramelteon is a selective melatonin receptor agonist (MT1 and MT2) that acts on the suprachiasmatic nucleus of the hypothalamus. By mimicking endogenous melatonin signaling, it supports circadian rhythm regulation and sleep initiation — without the sedative-hypnotic properties associated with benzodiazepines or Z-drugs. Ramelteon is not a controlled substance and is not associated with dependence or rebound insomnia.
Magnesium L-Threonate is a magnesium salt developed to enhance central nervous system penetration. Magnesium plays a role in neurotransmitter regulation, NMDA receptor modulation, and neuronal stability, supporting physiologic relaxation pathways relevant to sleep.
Together, this formulation is intended to support sleep onset through circadian signaling and neurophysiologic regulation.
SleepE combines a melatonin receptor agonist with a magnesium salt selected for its central nervous system penetration. Ramelteon mimics your body's natural melatonin signaling to support circadian rhythm regulation and sleep initiation, while Magnesium L-Threonate supports neurotransmitter regulation and neurologic relaxation.
Take as prescribed, typically once nightly 30–60 minutes before bedtime. Consistent timing may help support circadian rhythm regulation. Avoid alcohol or other sedative agents unless directed by your provider.
How it Works
Three easy steps to better sleep, backed by licensed medical guidance.
Step 1
Complete Your Sleep Assessment
Tell us about your sleep patterns, symptoms, medical history, and any medications you're currently taking.
Step 2
Personalized Provider Review
A licensed provider evaluates your information and determines the right sleep support option for you.
Step 3
Start Your Sleep Routine
If prescribed, your melatonin-based sleep support is sent to your preferred pharmacy or delivered directly to your door.
SleepE — What It Treats
SleepE combines Ramelteon 10mg and Magnesium L-Threonate 250mg in a mint-flavored chewable tablet to support sleep onset and circadian rhythm regulation — without the dependence risk of benzodiazepines or Z-drugs. It's commonly considered for difficulty falling asleep, jet lag, and shift-work-related sleep disruption.
Understanding SleepE: Use & Safety
What it is
SleepE pairs Ramelteon, a melatonin receptor agonist, with Magnesium L-Threonate for enhanced CNS penetration — together supporting circadian rhythm and neurologic relaxation for sleep onset.
Non-habit forming
Unlike benzodiazepines or Z-drugs, Ramelteon is not a controlled substance and is not associated with dependence or rebound insomnia when used as prescribed.
Safety first
Not appropriate for everyone — severe hepatic impairment, certain drug interactions, and pregnancy/breastfeeding require your provider's guidance before starting SleepE.
Need Help Sleeping? Let's Do It Safely.
SleepE is designed to help you fall asleep naturally and enjoy more consistent, restorative sleep. By supporting your body's natural sleep cycle, it helps you spend less time lying awake and more time getting the quality rest you need to wake up refreshed, focused, and ready for the day.
Unlike many traditional sleep medications, SleepE is formulated to support natural sleep without the habit-forming potential associated with many sedative-hypnotic medications. Every treatment begins with a confidential online consultation, allowing a licensed healthcare provider to determine if SleepE is the right solution for your sleep needs.
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Takashi Nakamura, MD
Board-Certified Emergency Medicine Physician
Dr. Nakamura specializes in holistic health and weight management via telehealth.
Takashi Nakamura, MD
Michael Wasef, MD
Board-Certified Internal Medicine Physician
Internal Medicine specialist focused on root-cause, patient-centered care via telemedicine.
Michael Wasef, MD
Laurie J. Mercier, MD
Chief Clinical Lead at Telegra
Laurie J. Mercier, MD, Chief Clinical Lead at Telegra, is a board-certified Family Medicine physician focused on evidence-based, patient-centered care.
Laurie J. Mercier, MD
Kimberli Hastings, NP
Family Nurse Practitioner
Family Medicine and Mental Health practitioner dedicated to collaborative, patient-centered care.
Kimberli Hastings, NP
Theresa Vergara, DNP, NP
Certified Nurse Practitioner
Theresa is a Columbia-trained Nurse Practitioner providing holistic, root-cause-focused care.
Theresa Vergara, DNP, NP
Kristine Clements, NP
Board Certified Family Nurse Practitioner
Board-certified Family Nurse Practitioner with 25+ years of experience, focused on functional medicine and patient-centered wellness.
Kristine Clements, NP
FAQs
Haven't found the answer? Reach out to us, and we will help you.
Yes, a prescription is required. You can complete a quick online consultation with our providers—no in-person visit needed.
Not always. Many sleep concerns can be evaluated online through a symptom review with a licensed provider. In some cases, a provider may recommend further evaluation if that's needed to safely address your symptoms.
Most patients hear back from a licensed provider within 24 hours.
If prescribed, your medication is shipped directly to your home in discreet packaging.
Some individuals choose to combine different wellness therapies based on their personal goals. Your healthcare provider can help determine whether a combination approach is appropriate for your needs and lifestyle.
If a provider determines that treatment is not appropriate, a full refund will be issued.
SleepE is generally well tolerated. Possible effects related to Ramelteon include dizziness, fatigue, headache, nausea, or rare abnormal dreams. Possible effects related to magnesium include mild gastrointestinal discomfort or loose stools. Your provider will discuss potential risks and benefits during your evaluation.
No. Ramelteon is not a controlled substance and is not associated with dependence or rebound insomnia, unlike benzodiazepines or Z-drugs. It can be taken regularly, as prescribed, without the risk of withdrawal.
SleepE may not be appropriate for individuals with known hypersensitivity to its ingredients, severe hepatic impairment, or those taking strong CYP1A2 inhibitors without medical supervision. It's also not recommended during pregnancy or breastfeeding unless specifically directed by a licensed clinician. A provider will screen your medical history before prescribing.
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